Journal
CURRENT ORGANIC CHEMISTRY
Volume 22, Issue 23, Pages 2256-2279Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1385272822666181008142138
Keywords
Anticancer; heterocyclic; nitrogen-containing heterocyclic; natural nitrogen-containing heterocyclic; synthetic nitrogen-containing heterocyclic
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Funding
- Iran National Science Foundation: INSF
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Cancer is one of the leading causes of death worldwide. Mutation of the cell regulates genes and protein causing cancer. Surgery, radiotherapy, and the use of anticancer agents are the current therapy of cancer despite their side effects. The general area of research relates to heterocyclic chemistry. The purpose of the article is to review the most recent advances in nitrogen-containing heterocyclics as possible chemotherapy agents for cancer. More than 90% of the novel drugs bear heterocyclics and among them, nitrogen-containing heterocyclic compounds show superior pharmaceutical effect than non-nitrogen compounds. Nitrogen-containing compounds, the heart of drug discovery, present a significant and valuable group of molecules that play a chief and vital role in the metabolism of living cells.
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