Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 53, Issue -, Pages 187-198Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2018.11.002
Keywords
-
Categories
Funding
- Canadian Institute of Health Research [BNIA342854, PJT374609]
Ask authors/readers for more resources
Poly(ADP-ribose) is a posttranslational modification and signaling molecule that regulates many aspects of human cell biology, and it is synthesized by enzymes known as poly(ADP-ribose) polymerases, or PARPs. A diverse collection of domain structures dictates the different cellular roles of PARP enzymes and regulates the production of poly(ADP-ribose). Here we primarily review recent structural insights into the regulation and catalysis of two family members: PARP-1 and Tankyrase. PARP-1 has multiple roles in the cellular response to DNA damage and the regulation of gene transcription, and Tankyrase regulates a diverse set of target proteins involved in cellular processes such as mitosis, genome integrity, and cell signaling. Both enzymes offer interesting modes of regulating the production and the target site selectivity of the poly(ADP-ribose) modification.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available