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Age (autoimmunity) associated B cells (ABCs) and their relatives

Journal

CURRENT OPINION IN IMMUNOLOGY
Volume 55, Issue -, Pages 75-80

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/j.coi.2018.09.007

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Funding

  1. USPHS [AI18785, AI128738]

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B cells affect human and animal health in numerous ways. They are the precursors for the antibody-secreting plasma cells and they also take up antigen, particularly antigen for which they bear-specific receptors, very efficiently and thus present antigen to T cells. The T cell-B cell interactions that thus occur serve not only to affect the B cell, but also, the T cell partner of the interaction. B cells are known to be quite heterogeneous. The different subpopulations of B cells contribute to different types of immune responses. Over the last 20 years it has become apparent that some B cells unexpectedly express a transcription factor, T-bet (Tbx21) that is conventionally associated with T cells. B cells expressing T-bet have been found in elderly female mice, in humans and mice infected with many different types of organisms, and in autoimmune mice. Where examined, the T-bet expressing B cells, or related cells, affect the course of the disease. For example, in patients of mice with autoimmunity the T-bet positive B cells, and their relatives, are the precursors for autoantibody production. Here we discuss the heterogeneity of T-bet expressing B cells and related cells.

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