Journal
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
Volume 18, Issue 12, Pages -Publisher
SPRINGER
DOI: 10.1007/s11910-018-0904-9
Keywords
Ischaemic stroke; SSRIs; Recovery from stroke; Brain plasticity; Neuroprotection; Post-stroke depression
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Purpose of ReviewThe interest in SSRIs after stroke has increased in the past few years, with better knowledge of post-stroke depression and with the demonstrated capacity of some SSRIs to act on the functional recovery of non-depressed subjects.Recent FindingsArguments for the action of SSRIs in favour of post-stroke neurological function recovery have improved through new elements: basic science and preclinical data, positive clinical trials and repeated series of stroke patient meta-analysis, and confirmation of favourable safety conditions in post-stroke patients.SummaryGlobal coherence is appearing, showing that SSRIs improve stroke recovery in non-depressed patients when given for 3months after the stroke, with highly favourable safety conditions and a favourable benefit/risk ratio. Large series are still needed.
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