Journal
CURRENT MEDICINAL CHEMISTRY
Volume 27, Issue 13, Pages 2189-2219Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/0929867325666181008142831
Keywords
Aptamer; cancer target therapy; drug delivery system; nanomaterials; drug carrier; nano-medicine
Funding
- Hunan Provincial Natural Science Foundation of China [2016JJ2161, 2017JJ2346]
- Huxiang Young Talent Program of Hunan Province [2018RS3005]
- Shenghua Yuying Project of Central South University
- Fundamental Research Funds for the Central Universities of Central South University
- Project of Innovation-driven Plan in Central South University [2020CX048]
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Aptamers are single-stranded DNA or RNA with 20-100 nucleotides in length that can specifically bind to target molecules via formed three-dimensional structures. These innovative targeting molecules have attracted an increasing interest in the biomedical field. Compared to traditional protein antibodies, aptamers have several advantages, such as small size, high binding affinity, specificity, good biocompatibility, high stability and low immunogenicity, which all contribute to their wide application in the biomedical field. Aptamers can bind to the receptors on the cell membrane and mediate themselves or conjugated nanoparticles to enter into cells. Therefore, aptamers can be served as ideal targeting ligands for drug delivery. Since their excellent properties, different aptamer-mediated drug delivery systems had been developed for cancer therapy. This review provides a brief overview of recent advances in drug delivery systems based on aptamers. The advantages, challenges and future prospectives are also discussed.
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