Journal
CURRENT MEDICAL RESEARCH AND OPINION
Volume 35, Issue 7, Pages 1241-1256Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/03007995.2019.1571297
Keywords
Lung cancer; cost-effectiveness; pembrolizumab; chemotherapy; United States
Funding
- Merck Sharp Dohme Corp.
- Kenilworth, NJ, USA
- Merck Co. Inc.
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Objective: To describe the cost-effectiveness of pembrolizumab plus chemotherapy (carboplatin and paclitaxel or nab-paclitaxel; P+C) in metastatic, squamous, non-small-cell lung cancer (NSCLC) patients in the US.Methods: A model comparing P+C versus C alone is developed utilizing partitioned survival analysis. Primary clinical efficacy, treatment utilization, health utility and safety data are derived from the KEYNOTE-407 trial and projected over 20years. Costs for drugs and non-drug disease management are also incorporated. Additionally, the cost-effectiveness of P+C vs. pembrolizumab monotherapy (P) is evaluated via an indirect treatment comparison, for patient subgroups with PD-L1 Tumor Proportion Score (TPS)50% and 1-49%.Results: Overall, P+C is projected to increase life expectancy by 1.95years vs. C (3.86 versus 1.91). The resultant ICER is $86,293/QALY. In patients with PD-L150%, 1-49% and <1 the corresponding incremental cost-effectiveness ratios (ICERs) are $99,777/QALY, $85,986/QALY and $87,507/QALY, respectively. Versus P, in the PD-L150% subgroup, P+C appears cost saving; however, this result should be interpreted with caution as there is considerable uncertainty in the relative efficacy of these comparators.Conclusions: Across all eligible patients, the addition of pembrolizumab to chemotherapy is projected to approximately double life expectancy, yielding an extension to a point not previously seen in metastatic squamous NSCLC. Overall, and within all relevant PD-L1 subgroups, use of P+C yields an ICER below $100,000/QALY, and can be a cost-effective first-line treatment for eligible metastatic squamous NSCLC patients for whom chemotherapy is currently administered. In the PD-L150% subgroup, additional follow-up within trials of pembrolizumab plus chemotherapy and pembrolizumab monotherapy are needed to better define cost-effectiveness between these comparators.
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