Journal
CURRENT HYPERTENSION REPORTS
Volume 21, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1007/s11906-019-0907-1
Keywords
Blood pressure; Inflammation; T cells; Natural killer cells; Dendritic cells; Macrophages; Antigen-presenting cells; Cytokines
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [102606, 123465]
- CIHR First Pilot Foundation [143348]
- Tier 1 Canada Research Chair (CRC) on Hypertension and Vascular Research, CRC Government of Canada/CIHR Program
- Canada Fund for Innovation
- Canadian Vascular Network
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Purpose of ReviewTo describe the important role played by innate and innate-like immunity in the pathophysiology of hypertension and vascular injury.Recent FindingsInnate immune cells, such as neutrophils, dendritic cells, myeloid-derived suppressor cells, and monocytes/macrophages and innate lymphoid cells such as natural killer cells and unconventional T lymphocytes like T cells contribute to hypertensive mechanisms by priming adaptive immune cells, leading to the triggering of vascular inflammation and blood pressure elevation or alternatively protecting against vascular injury. Specifically, monocyte/macrophages and T cells seem to play a crucial role in the initiation of hypertension via regulation of adaptive immunity.SummaryInnate and innate-like immunity play a leading role in the pathophysiology of hypertension. Recent advances in this field provide us clues for future therapeutic approaches.
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