Journal
CURRENT DRUG TARGETS
Volume 20, Issue 4, Pages 453-464Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450119666181026152221
Keywords
CDK9; cardiac pathway; cancer; viral agents; fibrosis; inflammation; RNAP
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Funding
- Molecular Medicine Research Center, Biomedicine institute, Tabriz University of Medical Sciences, Tabriz, Iran
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Cyclin Dependent Kinase 9 (CDK9) as a serine/threonine kinase belongs to a great number of CDKs. CDK9 is the main core of PTEF-b complex and phosphorylates RNA Polymerase (RNAP) II besides other transcription factors which regulate gene transcription elongation in numerous physiological processes. Multi-functional nature of CDK9 in diverse cellular pathways proposes that it is as an appealing target. In this review, we summarized the recent findings on the molecular interaction of CDK9 with critical participant molecules to modulate their activity in various diseases. Furthermore, the presented review provides a rationale supporting the use of CDK9 as a therapeutic target in clinical developments for crucial diseases; particularly cancers will be reviewed.
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