Journal
CURRENT DRUG TARGETS
Volume 20, Issue 6, Pages 625-634Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1389450120666181109092225
Keywords
Aryl hydrocarbon receptor; xenobiotics; carcinogenesis; transcription factor; post-translation modification; review
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Funding
- US Public Service Awards [CA090658, ES020591]
- NIEHS Center grant [ES000260]
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AhR is an environmental response gene that mediates cellular responses to a variety of xenobiotic compounds that frequently function as AhR ligands. Many AhR ligands are classified as carcinogens or pro-carcinogens. Thus, AhR itself acts as a major mediator of the carcinogenic effect of many xenobiotics in vivo. In this concise review, mechanisms by which AhR trans-activates down-stream target gene expression, modulates immune responses, and mediates malignant transformation and tumor development are discussed. Moreover, activation of AhR by post-translational modifications and crosstalk with other transcription factors or signaling pathways are also summarized.
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