Journal
CURRENT ALZHEIMER RESEARCH
Volume 16, Issue 3, Pages 243-250Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1567205016666190103161034
Keywords
Alzheimer's Disease; apolipoprotein E; sleep behaviours; Lewy bodies; risk factors; neuropathology; gender
Categories
Funding
- Canadian Institutes of Health Research (CIHR) [313912, P50 AG005131, P50 AG023501, P30 AG035982, P30 AG028383, P30 AG053760, P30 AG010124, P50 AG005133, P50 AG005142, P30 AG012300, P50 AG005136, P50 AG033514, P50 AG005681, P50 AG047270, P30 AG049638]
- NIA [P30 AG019610, P30 AG013846, P50 AG008702, P50 AG025688, P50 AG047266, P30 AG010133, P50 AG005146, P50 AG005134, P50 AG016574, P50 AG005138, P30 AG008051, P30 AG013854, P30 AG008017, P30 AG010161, P50 AG047366, P30 AG010129, P50 AG016573]
Ask authors/readers for more resources
Background: The Apolipoprotein (APOE) epsilon 4 allele is a well-known risk factor for Alzheimer's Disease (AD), and sleep disturbances are commonly associated with AD. However, few studies have investigated the relationship between APOE epsilon 4 and abnormal sleep patterns (N+) in AD. Objective: To examine the relationship between APOE genotype, Lewy body pathology, and abnormal sleep patterns in a large group of subjects with known AD load evaluated upon autopsy. Method: Data from 2,368 cases obtained from the National Alzheimer's Coordinating Centre database were categorized as follows: Braak Stage V/VI and CERAD frequent neuritic plaques as high load AD, Braak Stage III/IV and moderate CERAD as intermediate load AD, and Braak Stage 0/I/II and infrequent CERAD as no to low load AD. Cases discrepant between the two measures were discarded. Results: Disrupted sleep was more frequent in males (42.4%) compared to females (35.1%), and in carriers (42.3%) as opposed to non-carriers (36.5%) of epsilon 4. Amongst female subjects with high AD load and Lewy body pathology, homozygous (epsilon 4/epsilon 4) carriers experienced disrupted sleep more often compared with heterozygous (epsilon 4/x) or non-carriers of epsilon 4. Such recessive, gender-specific, and Lewy body association is reminiscent of the epsilon 4 effect on psychosis in AD. However, such association was lost after adjusting for covariates. In subjects with no to low AD pathology, female epsilon 4 carriers had significantly more nighttime disturbances than non-carriers; this effect is independent of the presence of Lewy body pathology. Conclusion: The influence of APOE epsilon 4 on sleep disturbances is dependent on gender and severity of AD load.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available