Journal
CONTRAST MEDIA & MOLECULAR IMAGING
Volume -, Issue -, Pages -Publisher
WILEY-HINDAWI
DOI: 10.1155/2018/1693513
Keywords
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Funding
- Alzheimer's Association [2015-NIRGD-342267, RO1 HD094347]
- NIH [R21EB020153]
- NCI Cancer Center support grant [CA016672]
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Fluorine-19 (F-19) magnetic resonance imaging (MRI) has the potential for a wide range of in vivo applications but is limited by lack of flexibility in exogenous probe formulation. Most F-19 MRI probes are composed of perfluorocarbons (PFCs) or perfluoropolyethers (PFPEs) with intrinsic properties which limit formulation options. Hydrophilic organofluorine molecules can provide more flexibility in formulation options. We report herein a hyperfluorinated hydrophilic organoflourine, ET1084, with similar to 24 wt. % F-19 content. It dissolves in water and aqueous buffers to give solutions with >= 8 M F-19. F-19 MRI phantom studies at 9.4T employing a 10-minute multislice multiecho (MSME) scan sequence show a linear increase in signal-to-noise ratio (SNR) with increasing concentrations of the molecule and a detection limit of 5 mM. Preliminary cytotoxicity and genotoxicity assessments suggest it is safe at concentrations of up to 20 mM.
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