Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 43, Issue -, Pages 1085-1088Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20150102
Keywords
biomarker; FOXO (forkhead box protein O); melanoma; phosphoinositide 3-kinase (PI3K); tribbles; TRIB2 (tribbles homolog 2)
Categories
Funding
- Bayer AG [2012-08-0765]
- Fundacao para a Ciencia e a Tecnologia (FCT) Research Center [UID/BIM/04773/2013 CBMR 1334]
Ask authors/readers for more resources
TRIB2 (tribbles homolog 2) encodes one of three members of the tribbles family in mammals. These members share a Trb (tribbles) domain, which is homologous to protein serine-threonine kinases, but lack the active site lysine. The tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. TRIB2 has been identified as an oncogene that inactivates the transcription factor CCAAT/enhancer-binding protein alpha (C/EBP alpha) and causes acute myelogenous leukaemia (AML). Recent research provided compelling evidence that TRIB2 can also act as oncogenic driver in solid tumours, such as lung and liver cancer. In particular, our recent work demonstrated that TRIB2 is dramatically overexpressed in malignant melanomas compared with normal skin and promotes the malignant phenotype of melanoma cells via the down-regulation of FOXO (forkhead box protein O) tumour suppressor activity in vitro and in vivo. TRIB2 was found to be expressed in normal skin, but its expression consistently increased in benign nevi, melanoma and was highest in samples from patients with malignant melanoma. The observation that TRIB2 strongly correlates with the progression of melanocyte-derived malignancies suggests TRIB2 as a meaningful biomarker to both diagnose and stage melanoma. In addition, interfering with TRIB2 activity might be a therapeutic strategy for the treatment of several different tumour types.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available