Journal
DIABETES & METABOLISM JOURNAL
Volume 39, Issue 1, Pages 10-15Publisher
KOREAN DIABETES ASSOC
DOI: 10.4093/dmj.2015.39.1.10
Keywords
Fetuin-A; Fibroblast growth factor 21; Hepatokines; Non-alcoholic fatty liver disease; Selenoprotein P
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Funding
- Basic Science Research Program through the National Research Foundation of Korea - Ministry of Education, Science and Technology [2012006363, 2012R1A1A1005257]
- Brain Korea 21 Project of the Ministry of Education and Human Resources Development, Republic of Korea
- Korea University
- National Research Foundation of Korea [2012R1A1A1005257] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Non-alcoholic fatty liver disease, which is considered a hepatic manifestation of metabolic syndrome, independently increases the risks of developing cardiovascular disease (CVD) and type 2 diabetes mellitus. Recent emerging evidence suggests that a group of predominantly liver-derived proteins called hepatokines directly affect the progression of atherosclerosis by modulating endothelial dysfunction and infiltration of inflammatory cells into vessel walls. Here, we summarize the role of the representative hepatokines fibroblast growth factor 21, fetuin-A, and selenoprotein P in the progression of CVD.
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