Journal
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
Volume 215, Issue -, Pages 25-32Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cbpc.2018.09.006
Keywords
Nonylphenol; Cadmium; Aromatase; Testosterone; 17 beta-estradiol; Vitellogenin
Funding
- Scientific Research Foundation of the Third Institute of Oceanography, State Oceanic Administration (SOA), China [2015006, 2015034, 2012019]
- National Natural Science Foundation of China [41206107]
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Nonylphenol (NP) and Cadmium (Cd) are two common contaminants that can be detected in aquatic environments. Nevertheless, the combined toxicity of NP and Cd at environmentally relevant concentrations in aquatic organisms has not been thoroughly characterized to date. In the present study, the interactions between NP and Cd on male Sebastiscus marmoratus were studied. After 21 days of exposure, the brain aromatase activity was observed to be significantly induced by 100 ng/L NP and 40 mu g/L Cd, whereas all of the concentrations of co-treatment resulted in an increase in brain aromatase activity. Additionally, NP could also reduce plasma testosterone concentration, while NP, Cd and their mixture could induce plasma 17 beta-estradiol (E2) concentration and VTG concentration. The interactions between NP and Cd on the reproductive physiology were antagonism. Our results also support the notion of using these indicators as biomarkers for exposure to EDCs and further extend the boundary of biomonitoring to environmental levels.
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