Journal
CLINICS IN CHEST MEDICINE
Volume 39, Issue 4, Pages 677-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ccm.2018.07.003
Keywords
Lung; Microbiome; Antibiotics; Immune responses; Inflammation; Bacterial taxa
Categories
Funding
- Flight Attendant Medical Research Institute Young Clinical Scientist Award [K23 A1102970]
- Stony Wold-Herbert Fund Fellowship
- [T32 CA193111]
- [UL1TR001445]
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The use of next-generation sequencing and multiomic analysis reveals new insights on the identity of microbes in the lower airways blurring the lines between commensals and pathogens. Microbes are not found in isolation; rather they form complex metacommunities where microbe-host and microbe-microbe interactions play important roles on the host susceptibility to pathogens. In addition, the lower airway microbiota exert significant effects on host immune tone. Thus, this review highlights the roles that microbes in the respiratory tract play in the development of pneumonia.
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