Related references
Note: Only part of the references are listed.Scientific white paper on concentration-QTc modeling
Christine Garnett et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2018)
Study Design Parameters Affecting Exposure Response Analysis of QT Data: Results From Simulation Studies
Georg Ferber et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2018)
Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cells to Assess Drug Cardiotoxicity: Opportunities and Problems
Tarek Magdy et al.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)
Assessing QT/QTc interval prolongation with concentration-QT modeling for Phase I studies: impact of computational platforms, model structures and confidence interval calculation methods
Jingtao Lu et al.
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS (2018)
Effects of moxifloxacin on the proarrhythmic surrogate markers in healthy Filipino subjects: Exposure-response modeling using ECG data of thorough QT/QTc study
Suchitra Matsukura et al.
JOURNAL OF PHARMACOLOGICAL SCIENCES (2018)
A Human Population-Based Organotypic In Vitro Model for Cardiotoxicity Screening
Fabian A. Grimm et al.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2018)
CiPA challenges and opportunities from a non-clinical, clinical and regulatory perspectives. An overview of the safety pharmacology scientific discussion
Rob Wallis et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2018)
Mechanistic Model-Informed Proarrhythmic Risk Assessment of Drugs: Review of the CiPA Initiative and Design of a Prospective Clinical Validation Study
Jose Vicente et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2018)
Comprehensive Translational Assessment of Human-Induced Pluripotent Stem Cell Derived Cardiomyocytes for Evaluating Drug-Induced Arrhythmias
Ksenia Blinova et al.
TOXICOLOGICAL SCIENCES (2017)
Stan: A Probabilistic Programming Language
Bob Carpenter et al.
JOURNAL OF STATISTICAL SOFTWARE (2017)
High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells
Arun Sharma et al.
SCIENCE TRANSLATIONAL MEDICINE (2017)
An Analysis of the Relationship Between Preclinical and Clinical QT Interval-Related Data
Christopher E. Pollard et al.
TOXICOLOGICAL SCIENCES (2017)
A Tiered, Bayesian Approach to Estimating Population Variability for Regulatory Decision-Making
Weihsueh A. Chiu et al.
ALTEX-ALTERNATIVES TO ANIMAL EXPERIMENTATION (2017)
Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative
Kiyoshi Takasuna et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2017)
Human-induced pluripotent stem cell approaches to model inborn and acquired metabolic heart diseases
Anita M. Chanana et al.
CURRENT OPINION IN CARDIOLOGY (2016)
Can an early phase clinical pharmacology study replace a thorough QT study? Experience with a novel H3-receptor antagonist/inverse agonist
Rashmi R. Shah et al.
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2016)
Human induced pluripotent stem cell-derived cardiomyocytes recapitulate the predilection of breast cancer patients to doxorubicin-induced cardiotoxicity
Paul W. Burridge et al.
NATURE MEDICINE (2016)
Induced pluripotent stem cells: at the heart of cardiovascular precision medicine
Ian Y. Chen et al.
NATURE REVIEWS CARDIOLOGY (2016)
Specific prediction of clinical QT prolongation by kinetic image cytometry in human stem cell derived cardiomyocytes
Emily R. Pfeiffer et al.
JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2016)
High-Content Assay Multiplexing for Toxicity Screening in Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Hepatocytes
Fabian Alexander Grimm et al.
ASSAY AND DRUG DEVELOPMENT TECHNOLOGIES (2015)
Evaluation of drug-induced QT interval prolongation in animal and human studies: a literature review of concordance
Hugo M. Vargas et al.
BRITISH JOURNAL OF PHARMACOLOGY (2015)
Concise Review: Cardiac Disease Modeling Using Induced Pluripotent Stem Cells
Chunbo Yang et al.
STEM CELLS (2015)
Evolving Electrocardiographic Changes in Lamotrigine Overdose: A Case Report and Literature Review
Patricia Chavez et al.
CARDIOVASCULAR TOXICOLOGY (2015)
Application of Mass Balance Models and the Chemical Activity Concept To Facilitate the Use of in Vitro Toxicity Data for Risk Assessment
James M. Armitage et al.
ENVIRONMENTAL SCIENCE & TECHNOLOGY (2014)
Stem Cells and Stem Cell-derived Tissues and Their Use in Safety Assessment
Kyle Kolaja
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Incorporating Population Variability and Susceptible Subpopulations into Dosimetry for High-Throughput Toxicity Testing
Barbara A. Wetmore et al.
TOXICOLOGICAL SCIENCES (2014)
A case series of patients with lamotrigine toxicity at one center from 2003 to 2012
P. W. Moore et al.
CLINICAL TOXICOLOGY (2013)
The impact of drug-related QT prolongation on FDA regulatory decisions
Eunjung Park et al.
INTERNATIONAL JOURNAL OF CARDIOLOGY (2013)
Multiparameter In Vitro Assessment of Compound Effects on Cardiomyocyte Physiology Using iPSC Cells
Oksana Sirenko et al.
JOURNAL OF BIOMOLECULAR SCREENING (2013)
The Cost-Effectiveness of Drug Regulation: The Example of Thorough QT/QTc Studies
J. C. Bouvy et al.
CLINICAL PHARMACOLOGY & THERAPEUTICS (2012)
How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?
H. G. Laverty et al.
BRITISH JOURNAL OF PHARMACOLOGY (2011)
Assessment of QT liabilities in drug development
C. Arrigoni et al.
CELL BIOLOGY AND TOXICOLOGY (2007)
Effects of three Fluoroquinolones on QT analysis after standard treatment courses
JP Tsikouris et al.
ANNALS OF NONINVASIVE ELECTROCARDIOLOGY (2006)
Risk factors for prolonged QTc among US adults: Third National Health and Nutrition Examination Survey
SR Benoit et al.
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION (2005)
Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development
WS Redfern et al.
CARDIOVASCULAR RESEARCH (2003)
Share Paper
