Journal
CLINICAL LUNG CANCER
Volume 20, Issue 3, Pages E393-E401Publisher
CIG MEDIA GROUP, LP
DOI: 10.1016/j.cllc.2018.12.008
Keywords
Immunotherapy; Lymphoepithelioma-like carcinoma of the lung; NSCLC; Rare tumor; Treatment
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Lymphoepithelioma-like carcinoma of the lung (LELC) is a rare, Epstein-Barr virus-associated tumor. LELC occurs mostly in young, Asian nonsmokers. A few hundred cases have been reported, mostly from retrospective Asian studies. Optimal treatment has not been clearly established. Treatment options are based on surgery for early stage and on cisplatin-based chemotherapy as first-line therapy for metastatic disease. Prognosis may seem better than for other types of non-small-cell lung cancer, but it remains poor in advanced disease, with a median survival of 24 months, and new treatments options are still warranted. Immunotherapies are now key players in the treatment of non-small-cell lung cancer. However, few data are available for this rare histologic subgroup. We have reviewed the available data on LELC with a focus on the first few cases reported with a response to a programmed cell death 1 inhibitor. (C) 2018 Elsevier Inc. All rights reserved.
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