Journal
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
Volume 13, Issue -, Pages 459-468Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.csbj.2015.08.003
Keywords
Knotted proteins; Protein folding; Molecular simulations; Kinetic stability; Protein evolution
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Knotted proteins have their native structures arranged in the form of an open knot. In the last ten years researchers have been making significant efforts to reveal their folding mechanism and understand which functional advantage(s) knots convey to their carriers. Molecular simulations have been playing a fundamental role in this endeavor, and early computational predictions about the knotting mechanism have just been confirmed in wet lab experiments. Here we review a collection of simulation results that allow outlining the current status of the field of knotted proteins, and discuss directions for future research. (C) 2015 Faisca. Published by Elsevier B.V.
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