Journal
JOURNAL OF ADVANCED RESEARCH
Volume 6, Issue 3, Pages 363-373Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jare.2014.10.006
Keywords
Biginelli adducts; Antiproliferative activity cancer; Calcium channel; Antimicrobial activity; Antioxidants
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Since the disclosure of Biginelli reaction by the chemist Pietro Biginelli, functionalized 3,4-dihydropyrimidin-2(1H)-ones/thiones (DHPMs) have emerged as prototypes for the design of compounds with a broad variety of biological activities. This mini-review describes over 100 Biginelli adducts demonstrated to be promising anticancer, inhibitors of calcium channel, anti-inflammatory, antimicrobial and antioxidant agents. Thus, this compilation presents the most notable in vitro and in vivo results for such fascinating class of organic compounds. (C) 2014 Production and hosting by Elsevier B.V. on behalf of Cairo University.
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