Journal
WORLD JOURNAL OF STEM CELLS
Volume 7, Issue 2, Pages 343-351Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4252/wjsc.v7.i2.343
Keywords
Mesenchymal stem cell; Hematopoietic stem cell; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Amniotic fluid stem cells; Induced pluripotent stem cells; Intestinal stem cells; Endothelial progenitor cells; Tolerogenic immune cell therapies
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Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells (regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient's immune system, and repairs the injured tissue.
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