Journal
CLIMACTERIC
Volume 21, Issue 6, Pages 613-616Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13697137.2018.1514005
Keywords
Fertility preservation; ovarian tissue cryopreservation; transplantation; first case; China
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Funding
- Beijing Municipal Administration of Hospitals Clinical medicine, Development of Special Funding Support [XMLX201710]
- Capital's Funds for Health Improvement and Research [2016-2-2113]
- Beijing Municipal Science & Technology Commission [Z161100000516143]
- Beijing Municipal Administration of Hospitals' Ascent Plan [DFL20181401]
- SAFEA: Project for Key Foreign Experts [20181100005]
- Beijing Nature Science Foundation [Y181004]
- Beijing Municipality Health Technology High-level Talent [2014-2-016]
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Ovarian tissue cryopreservation and retransplantation has been offered as a fertility preservation approach for over a decade. At least 130 live births have been reported after frozen-thawed ovarian tissue transplantation worldwide. The first International Fertility Protection Center in China was established in 2015. Until now no live birth has been reported. However, we are able to report the first Chinese successful retransplantation of cryopreserved ovarian tissue (September 2016) in a woman with squamous cell cervical carcinoma. Restoration of ovarian endocrine function was shown in the third month after transplantation, and after 21 months of follow-up the transplants are still active and maintaining good function. This first report of successful retransplantation represents a milestone in the field of fertility preservation in China.
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