Journal
CIRCULATION RESEARCH
Volume 124, Issue 2, Pages 315-327Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.313591
Keywords
adaptive immunity; atherosclerosis; immunity; inflammation; myeloid cells; vaccination
Funding
- Deutsche Forschungsgemeinschaft [DFG WO1994/1, HL115232, HL88093, HL121697]
- National Heart, Lung, and Blood Institute
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There is now overwhelming experimental and clinical evidence that atherosclerosis is a chronic inflammatory disease. Lessons from genome-wide association studies, advanced in vivo imaging techniques, transgenic lineage tracing mice, and clinical interventional studies have shown that both innate and adaptive immune mechanisms can accelerate or curb atherosclerosis. Here, we summarize and discuss the pathogenesis of atherosclerosis with a focus on adaptive immunity. We discuss some limitations of animal models and the need for models that are tailored to better translate to human atherosclerosis and ultimately progress in prevention and treatment.
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