Journal
CIRCULATION RESEARCH
Volume 123, Issue 10, Pages 1118-1120Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCRESAHA.118.313816
Keywords
atherosclerosis; autoimmunity; interleukin-1; peripheral vascular disease; stroke; vaccination
Funding
- National Institutes of Health [R01 HL121697, P01 HL088093, R01 HL126543, P01 HL136275]
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Atherosclerosis is a chronic inflammatory disease of large and medium-sized arteries that causes ischemic heart disease, strokes, and peripheral vascular disease collectively called cardiovascular disease (CVD). Atherosclerosis requires elevated LDL (low-density lipoprotein) cholesterol, which can be controlled by statins and PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibitors. Both effectively control LDL cholesterol and reduce major adverse cardiovascular events by approximate to 50%.(1)
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