Journal
CIRCULATION
Volume 139, Issue 18, Pages 2089-2097Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/CIRCULATIONAHA.118.037076
Keywords
hypertension; natriuretic peptides; sodium-glucose transporter 2 inhibitors; type 2 diabetes mellitus
Funding
- Boehringer Ingelheim
- Eli Lilly and Company Diabetes Alliance
Ask authors/readers for more resources
BACKGROUND: The risk of cardiovascular disease and mortality in salt-sensitive patients with diabetes mellitus and uncontrolled nocturnal hypertension is high. The SACRA (Sodium-Glucose Cotransporter 2 [ SGLT2] Inhibitor and Angiotensin Receptor Blocker [ ARB] Combination Therapy in Patients With Diabetes and Uncontrolled Nocturnal Hypertension) study investigated changes in blood pressure (BP) with empagliflozin plus existing antihypertensive therapy. METHODS: This multicenter, double-blind, parallel study was conducted in Japan. Adult patients with type 2 diabetes mellitus and uncontrolled nocturnal hypertension receiving stable antihypertensive therapy including angiotensin receptor blockers were randomized to 12 weeks' treatment with empagliflozin 10 mg once daily or placebo. Clinic Bpwas measured at baseline and weeks 4, 8, and 12; 24-hour ambulatory Bpmonitoring was performed at baseline and week 12; and morning home Bpwas determined for 5 days before each visit. The primary efficacy end point was change from baseline in nighttime Bp(ambulatory Bpmonitoring). RESULTS: One hundred thirty-two nonobese, older patients with well-controlled blood glucose were randomized (mean age 70 years, mean body mass index 26 kg/ m2). Empagliflozin, but not placebo, significantly reduced nighttime systolic Bpversus baseline (-6.3 mm Hg; P= 0.004); between-groupdifference in change from baseline was -4.3 mm Hg (P= 0.159). Reductions in daytime, 24-hour, morning home, and clinic systolic Bpat 12 weeks with empagliflozin were significantly greater than with placebo (-9.5, -7.7, -7.5, and -8.6 mm Hg, respectively; all P= 0.002). Between-group differences in body weight and glycosylated hemoglobin reductions were significant, but small (-1.3 kg and -0.33%; both P< 0.001). At 4 weeks, N-terminal pro-B-type natriuretic peptide levels were reduced to a greater extent in the empagliflozin versus placebo group(-12.1%; P= 0.013); atrial natriuretic peptide levels decreased with empagliflozin versus placebo at weeks 4 and 12 (-8.2% [ P= 0.008] and -9.7% [ P= 0.019]). Changes in antihypertensive medication during the study did not differ significantly between groups. CONCLUSIONS: Nonseverely obese older diabetes patients with uncontrolled nocturnal hypertension showed significant Bpreductions without marked reductions in glucose with the addition of empagliflozin to existing antihypertensive and antidiabetic therapy. Use of sodium-glucose cotransporter 2 inhibitors in specific groups (eg, those with nocturnal hypertension, diabetes, and high salt sensitivity) could helpreduce the risk of heart failure and cardiovascular mortality. CLINICAL TRIAL REGISTRATION: URL: https:// www. clinicaltrials. gov. Unique identifier: NCT03050229.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available