Journal
CHROMOSOME RESEARCH
Volume 27, Issue 1-2, Pages 19-30Publisher
SPRINGER
DOI: 10.1007/s10577-018-9591-2
Keywords
rDNA; Ribosomal DNA; Epigenetics
Funding
- NIH Director's Transformative ResearchAward [1R01GM123640]
- UA. Cancer Center Core Grant [P30CA023074]
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Our goal is to draw a linehypothetical in its totality but experimentally supported at each individual stepconnecting the ribosomal DNA and the phenomenon of transgenerational epigenetic inheritance of induced phenotypes. The reasonableness of this hypothesis is offset by its implication, that many (or most) (or all) of the cases of induced-and-inherited phenotypes that are seen to persist for generations are instead unmapped induced polymorphisms in the ribosomal DNA, and thus are the consequence of the peculiar and enduringly fascinating genetics of the highly transcribed repeat DNA structure at that locus.
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