Journal
CHINESE CHEMICAL LETTERS
Volume 30, Issue 3, Pages 563-565Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.12.017
Keywords
Fluorescent probe; Biothiol; Water-soluble; Red-emitting; Large Stokes shift
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Funding
- National Natural Science Foundation of China [U1608222]
- Special Fund for Agro-scientific Research in the Public Interest of China [201503108]
- Fundamental Research Funds for the Central Universities of Central South University [2018zzts109]
- State Key Laboratory of Chemo/Biosensing and Chemometrics [2016005]
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In this work, we presented a fluorescent probe (MCQ-DNBS) for selective and sensitive detection of biothiols based on a methylated chromenoquinoline (MCQ) derivative. Probe MCQ-DNBS was constructed by masking the OH group in MCQ with a common sensing unit, 2,4-dinitrobezensulfonate group (DNBS) for biothiols. Due to the photo-induced electron transfer (PET) process between MCQ and DNBS, this probe was weekly fluorescent. Upon the addition of biothiols (Cys, Hcy and GSH), this probe emitted a strong red fluorescence (lambda(em max)= 613 nm) with a large Stokes shift (115 nm). In addition, fluorescence imaging of biothiols in living cells was successfully realized using MCQ-DNBS as a detector. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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