Journal
CHINESE CHEMICAL LETTERS
Volume 30, Issue 3, Pages 664-667Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2018.10.021
Keywords
Microcystin-LR; Metal-organic frameworks; MIL-101; Competitive; Electrochemical immunosensor
Categories
Funding
- National Natural Science Foundation of China [21165023,21465026, 21765026, 21605130]
- National Key Scientific Program of China [2011CB911000, 01100205020503104]
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An electrochemical immunosensor was developed for ultrasensitive detection of microcystin-LR in water. MIL-101, a porous metal-organic frameworks (MOFs) material based on trivalent chromium skeleton were synthesized by hydrothermal synthesis method, and loaded with Au nanoparticles (Au NPs) to prepare Au NPs@MIL-101 composite materials which were used as a marker to label anti microcystin-LR (Anti-MC-LR). The composite materials have strong catalytic properties to the oxidation of ascorbic acid. Anti-MC-LR was immobilized on glassy carbon electrode surface using electrodeposition graphene oxide (GO) as an immobilization matrix to construct a competitive microcystin-LR immunosensor. The electrochemical immunosensor display linear relationship in the range of 0.05 ng/mL-75 mu g/mL with linear correlation coefficient of 0.9951 and detection limit of 0.02 ng/mL (S/N = 3). This sensor was used to detect microcystin-LR in the water sample. The recovery was 102.43%, which is satisfied. The good testing results indicate the sensor has a great prospect in practical application. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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