Cell microarray chip system for accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3

Breast cancer is one of the most common cancers in the world, survival rates of breast cancer are rising as screening and treatment improve. Many new technologies applied in the biomedical domain have been born for rapid diagnosis and treatment. In this work, visualization cell microarray chip with three-dimensional (3D) embedded cell scaffold for cell diagnosis and treatment was designed. DNA segment, targeting on breast cancer cells SK-BR-3, were modified with camptothecin and used as model drug. Cell microarray chip system successfully control the diffusion of small molecules and locally introduced the compounds into cells. 3D embedded cell scaffold in the cell array chip afforded an environment with continuous medium supplementary and help controlling the diffusion of small molecules drugs. By cell microarray chip system, SK-BR-3 was targeted screening and killing in one step. Cell microarray chip system can achieve accurate, rapid diagnosis and target treatment of breast cancer cells SK-BR-3 and have a potential to develop to be an effective and accurate drug screen method for evaluating the drug effect of the booming chemicals. (C) 2019 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.