Journal
CHINESE CHEMICAL LETTERS
Volume 29, Issue 11, Pages 1685-1688Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2017.12.004
Keywords
Bovine serum albumin; Manganese dioxide; Photothermal; NIR; Cancer therapy
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Funding
- National Natural Science Foundation of China [81601632]
- Natural Science Foundation of Jiangsu Province [SBK2016041233]
- Fundamental Research Funds for Central Universities [021314380067]
- Thousand Talents Program for Young Researchers, NIH [1R21CA190024-01]
- DOD [W81XWH-12-1-0414]
- Houston Methodist Research Institute
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More recently, the biomedical applications of MnO2 in bioanalysis, cell imaging, and drug delivery as a result of their appealing physicochemical properties, have been reported and expanded rapidly. However, research on a near infrared (NIR) photothermal response of MnO2 was ignored. In this work, we reported a facile, one-pot method to synthesis of bovine serum albumin (BSA)-reduced and stabilized MnO2 nanoparticles (BSA-MnO2 NPs) with good aqueous dispersibility and high biocompatibility. And we also showed for the first time that BSA-MnO2 NPs displayed superior NIR photothermal efficiency and photostability which demonstrated as a novel class of photothermal antitumor agent. (C) 2018 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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