Journal
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
Volume 10, Issue 1, Pages 13-23Publisher
HONG KONG ASIAMED PUBLISH HOUSE
DOI: 10.1016/j.ajps.2014.08.005
Keywords
Nanocrystals; Bioavailability; Poorly water-soluble drugs
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Nanocrystals, a carrier-free colloidal delivery system in nano-sized range, is an interesting approach for poorly soluble drugs. Nanocrystals provide special features including enhancement of saturation solubility, dissolution velocity and adhesiveness to surface/cell membranes. Several strategies are applied for nanocrystals production including precipitation, milling, high pressure homogenization and combination methods such as Nano-Edge (TM), SmartCrystal and Precipitation-lyophilization-homogenization (PLH) technology. For oral administration, many publications reported useful advantages of nanocrystals to improve in vivo performances i.e. pharmacokinetics, pharmacodynamics, safety and targeted delivery which were discussed in this review. Additionally, transformation of nanocrystals to final formulations and future trends of nanocrystals were also described. (C) 2015 Shenyang Pharmaceutical University. Production and hosting by Elsevier B.V.
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