Journal
CHEMSUSCHEM
Volume 12, Issue 6, Pages 1147-1154Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cssc.201802815
Keywords
acylation; asymmetric chemistry; chemoselectivity; green solvents; organolithium
Funding
- University of Vienna
- Stockholm University
Ask authors/readers for more resources
The well-established Hoppe-Beak chemistry, which involves enantioselective generation of organolithium compounds in the presence of (-)-sparteine, was revisited and applied to unprecedented acylations with Weinreb amides to access highly enantioenriched alpha-oxyketones and cyclic alpha-aminoketones. Recycling of the sustainable solvent cyclopentyl methyl ether, sparteine, and the released Weinreb amine [HNMe(OMe)] was possible through a simple work-up procedure that enabled full recovery of these precious materials. The methodology features a robust scope and flexibility, thus allowing the enantioselective preparation of scaffolds amenable of further derivatization.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available