Journal
CHEMMEDCHEM
Volume 14, Issue 2, Pages 190-216Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cmdc.201800693
Keywords
bisphosphonates; nucleotides; organophosphorus compounds; phosphorus; prodrugs
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Funding
- Consejo Nacional de Investigaciones Cientificas y Tecnicas [PIP 112-201501-00631 CO, PIP 112-201501-00366 CO]
- Agencia Nacional de Promocion Cientifica y Tecnologica [1349]
- Universidad de Buenos Aires [20020170100067BA, 20020150100070BA]
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Although the phosphorus atom is found in a variety of oxidation states, most of the phosphorus-containing molecules of pharmacological importance possess phosphorus in the form of phosphonate or phosphinate functional groups, or in a major oxidation state as a phosphate group. The most common occurrence of phosphorus in drugs is either in prodrugs or in compounds for which the phosphorus atom plays a role in the biological activity, such as in modified nucleotides, in metabolically stable analogues of metabolites bearing phosphate groups, and as bioisosteric analogues of carboxyl groups.
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