Journal
CHEMISTRY-AN ASIAN JOURNAL
Volume 14, Issue 3, Pages 344-388Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/asia.201801560
Keywords
aldehydes; amides; amines; ketones; oximes
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Funding
- FUNDECT, Brazil
- Institute of Chemistry at UFMS
- Young Talent Fellowship under the Brazil Scientific Mobility Program of the National Council for Scientific and Technological Development (CNPq) Science Without Borders [304592/2014-5]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior, Brazil (CAPES) [001]
- CNPq, Brazil
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The formation of amide bonds is one of the most stimulating emerging areas in organic and medicinal chemistry. Amides are recognized as central building blocks in a plethora of interesting pharmaceuticals, proteins, peptides, polymers, natural products, functional materials, and biologically relevant carbocyclic or heterocyclic molecules, and they are also found in a variety of industrial fields. Therefore, a review of recent developments and challenges in the formation of amide bonds from carbonyl compounds is particularly important. Herein, we have scrutinized a range of metal-catalyzed and metal-free approaches for the synthesis of amides from aldehydes, ketones, and oximes. In addition, this Minireview highlights relevant mechanistic studies, as well as the potential applications of these methods in the synthesis of candidate drug molecules. We hope that the data compiled herein will encourage further progress in this notable area of chemistry research.
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