Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 14, Pages 3617-3626Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201805436
Keywords
click chemistry; fluorescent probes; imaging agents; nitrogen heterocycles; phosphonates
Categories
Funding
- Universita Ca' Foscari
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The synthesis of a conjugate molecule between an unusual red-fluorescent diketopyrrolopyrrole (DPP) unit and a bis-phosphonate (BP) precursor by a click-chemistry strategy to target bone tissue and monitor the interaction is reported. After thorough investigation, conjugation through a triazole unit between a gamma-azido rather than a beta-azido BP and an alkyne-functionalized DPP fluorophore group turned out to be the winning strategy. Visualization of the DPP-BP conjugate on osteoclasts and specific antiresorption activity were successfully demonstrated.
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