Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 19, Pages 4871-4884Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201804970
Keywords
biosynthesis; crystal growth; enzymes; in situ product removal; process intensification
Categories
Funding
- DFG (Deutsche Forschungsgemeinschaft) [LA 4183/1-1]
- DFG [KR 2491/11-1]
- BMBF (Bundesministerium fur Bildung und Forschung) [031A123]
- Leibniz Science Campus Phosphorus Research Rostock
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This Minireview highlights the application of crystallization as a very powerful in situ product removal (ISPR) technique in biocatalytic process design. Special emphasis is placed on its use for in situ product crystallization (ISPC) to overcome unfavorable thermodynamic reaction equilibria, inhibition, and undesired reactions. The combination of these unit operations requires an interdisciplinary perspective to find a holistic solution for the underlying bioprocess intensification approach. Representative examples of successful integrated process options are selected, presented, and assessed regarding their overall productivity and applicability. In addition, parallels to the use of adsorption as a very similar technique are drawn and similarities discussed.
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