Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 3, Pages 750-753Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201805097
Keywords
allenes; enones; E-selective; thermodynamically controlled product; trifluoromethylation
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Funding
- Cariplo Foundation, Italy
- SERB [EMR/2015/000164]
- Lombardy Region, Italy
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A silver(I) catalyzed regioselective trifluoromethylation of allenes using Langlois's salt (NaOSOCF3) is demonstrated. This transformation enables direct expedient access to alpha-trifluoromethylated acroleins, which are valuable synthons for a number of pharmaceuticals and agrochemicals containing vinyl-CF3 moieties. Versatility of this trifluoromethylation method has been established with good yield and excellent regioselectivity. Preliminary experiments and computational studies were carried out to elucidate the mechanistic insight of this protocol.
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