Journal
CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 7, Pages 1716-1721Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201805680
Keywords
cascade reactions; enzyme immobilization; heterogeneous catalysis; metal-organic frameworks; Pd nanoparticles
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Funding
- Thousand Talents Program [1800-16GH030121]
- China Postdoctoral Science Foundation [2017M623231]
- Fundamental Research Funds for the Central Universities [3102018zy051]
- DFG [WU 814/1-1]
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In cooperative catalysis, the combination of chemo- and biocatalysts to perform one-pot reactions is a powerful tool for the improvement of chemical synthesis. Herein, UiO-66-NH2 was employed to stepwise immobilize Pd nanoparticles (NPs) and Candida antarctica lipase B (CalB) for the fabrication of biohybrid catalysts for cascade reactions. Distinct from traditional materials, UiO-66-NH2 has a robust but tunable structure that can be utilized with a ligand exchange approach to adjust its hydrophobicity, resulting in excellent catalyst dispersity in diverse reaction media. These attractive properties contribute to the formation of MOF-based biohybrid catalysts with high activity and selectivity in the synthesis of benzyl hexanoate from benzaldehyde and ethyl hexanoate. With this proof-of-concept, we reasonably expect that future tailor-made MOFs can combine other catalysts, ranging from chemical to biological catalysts for applications in industry.
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