4.6 Review

N-Boc-Amides in Cross-Coupling Reactions

Journal

CHEMISTRY-A EUROPEAN JOURNAL
Volume 25, Issue 11, Pages 2663-2674

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/chem.201802635

Keywords

amides; Boc activation; C-N activation; cross-coupling; homogeneous catalysis

Funding

  1. Ministere de lEnseignement Superieur et de la Recherche
  2. CNRS
  3. Ecole Polytechnique

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Since 2015, the use of amides as electrophilic partners in cross-coupling reactions has experienced exponential growth. Diverse amide derivatives have been studied and among them N-Boc-amides have shown good activities towards various cross-coupling reactions and presents, in our view, an important synthetic usefulness. This review describes the recent developments of these chemical transformations involving N-Boc-amides.

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