Journal
CHEMICAL RECORD
Volume 19, Issue 5, Pages 843-858Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/tcr.201800149
Keywords
nanomaterials; peptides; self-assembly; artificial viral capsid; nanofiber; microtubules
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Funding
- PRESTO, Japan Science and Technology Agency (JST), KAKENHI from the Japan Society for the Promotion of Science (JSPS) [17K14517, 15H03838, 18H02089, 18H04558, 24104004]
- Grants-in-Aid for Scientific Research [18H04558, 24104004, 18H02089, 15H03838, 17K14517] Funding Source: KAKEN
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Natural supramolecular assemblies exhibit unique structural and functional properties that have been optimized over the course of evolution. Inspired by these natural systems, various bio-nanomaterials have been developed using peptides, proteins, and nucleic acids as components. Peptides are attractive building blocks because they enable the important domains of natural protein assemblies to be isolated and optimized while retaining the original structures and functions. Furthermore, the peptide subunits can be conjugated with exogenous molecules such as peptides, proteins, nucleic acids, and metal nanoparticles to generate advanced functions. In this personal account, we summarize recent progress in the construction of peptide-based nanomaterial designed from natural supramolecular systems, including (1) artificial viral capsids, (2) self-assembled nanofibers, and (3) protein-binding motifs. The peptides inspired by nature should provide new design principles for bio-nanomaterials.
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