Journal
CHEMBIOCHEM
Volume 20, Issue 5, Pages 667-671Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.201800648
Keywords
cancer; gold; nanoparticles; photo-crosslinking; photothermal therapy; cross-coupling
Funding
- National Key Research and Development Program of China [2016YFC0101200]
- National Natural Science Foundation of China [21572153]
- Key Research and Development Program of Social Development of Jiangsu Province [BE2018655]
- Natural Science Foundation of Jiangsu Educational Committee [15KJA310004]
- Suzhou Science and Technology Program [SYG201520]
- Open Project Program of the State Key Laboratory of Radiation Medicine and Protection [GZK1201819]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
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Manipulating the cross-coupling of gold nanoparticles (AuNPs) to maximize the photothermal effect is a promising strategy for cancer therapy. Here, by taking advantage of the well-known tetrazole/alkene photoclick chemistry, we have demonstrated for the first time that small AuNPs (23nm) decorated with both 2,5-diphenyltetrazole and methacrylic acid on their surfaces can form covalently crosslinked aggregates upon laser irradiation (=405nm). In vitro studies indicated that the light-triggered assembling shifted the surface plasmon resonance of AuNPs significantly to near-infrared (NIR) regions, which as a consequence effectively enhanced the efficacy of photothermal therapy for 4T1 breast cancer cells. We thus believe that this new light-triggered cross-coupling approach might offer a valuable tool for cancer treatment.
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