Journal
CERAMICS INTERNATIONAL
Volume 45, Issue 5, Pages 5996-6003Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ceramint.2018.12.070
Keywords
GO-IONP; Chitosan; Dextran; LBL Layer-by-layer; Drug delivery
Categories
Funding
- National Natural Science Foundation of China [21506079]
- Jiangsu University Scientific Research Funding [14JDG164]
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Iron oxide nanoparticle-modified graphene oxide nanosheets (GO-IONP) is a potential material for biomedical use, while its application is seriously limited due to its poor dispersibility under physiological conditions. In this work, GO-IONP was stabilized by chitosan and dextran via layer-by-layer self-assembly to produce GO-IONP-CS/DEX nanocomposites for targeted drug delivery and photothermal ablation. After the modification, its hydrophilic performance was enhanced, with the aggregation under physiological conditions strongly improved and undesired non-specific protein absorption ratio drastically reduced. Nanocomposites could load DOX up to 140.1% and DOX-loaded nanocomposites performed a sustained and pH-dependent drug releasing behavior. Moreover, the magnetic nanocomposites can be internalized by A549 cells with a magnetically targeted drug delivery profile. Pure GO-IONP-CS/DEX had an excellent photothermal ablation effect with no obvious cytotoxicity, and GO-IONP-CS/DEX-DOX had a cytotoxicity that increased with drug dose. All in all, GO-IONP-CS/ DEX had good prospects for the biomedical delivery application.
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