Journal
CELLULAR MICROBIOLOGY
Volume 21, Issue 3, Pages -Publisher
WILEY
DOI: 10.1111/cmi.12997
Keywords
phagocytes; phagosomal escape; Staphylococcus aureus
Categories
Funding
- Deutsche Forschungsgemeinschaft [TRR34]
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Staphylococcus aureus is internalised by host cells in vivo, and recent research results suggest that the bacteria use this intracellularity to persist in the host and form a reservoir for recurrent infections. However, in different cells types, the pathogen resorts to alternative strategies to survive phagocytosis and the antimicrobial mechanisms of host cells. In non-professional phagocytes, S. aureus either escapes the endosome followed by cytoplasmic replication or replicates within autophagosomes. Professional phagocytes possess a limited capacity to kill S. aureus and hence the bacteria, well equipped with immune evasive mechanisms, replicate within the cells, eventually lyse out of the cells and thus persist in a continuous cycle of phagocytosis, host cell death, and bacterial release.
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