Journal
CELLULAR IMMUNOLOGY
Volume 335, Issue -, Pages 6-14Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.cellimm.2018.10.004
Keywords
Natural killer cells; Cytotoxic T cells; Autoimmunity
Categories
Funding
- National Natural Science Foundation of China [81770110, 81600554, 81570106, 81370607, 81570111, 81400085, 81400088]
- Natural Science Foundation of Tianjin City [16ZXMJSY00180, 17JCQNJC10200, 14JCYBJC25400, 15JCYBJC24300]
- Tianjin Municipal University Science and Technology Development Fund Project [20140109]
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The roles of natural killer (NK) cells in shaping the immune system had raised wide interests. Here we intended to explore the regulatory functions of NK cells on CD8(+) T cells in severe aplastic anemia (SAA) using human participants and lymphocyte infusion-induced bone marrow failure (BMF) mouse model. In SAA patients, NK cells had over-expressions of NKG2D and NKp46, under-expression of NKG2A and enhanced cytotoxicity. NK cells limited autologous CD8(+) T cell immunity in an effector/target ratio manner. The suppression was dependent on the existence of NKG2D. We also observed upregulated MICA expression on activated CD8(+) T cells, which were susceptible to NK cell mediated lysis in SAA. Animal model concurred with the data from patients. Infusion of NK cells suppressed the proliferation of CD8(+) T cells and decreased IFN-gamma production. In conclusion, NK cells served NKG2D-dependent immunoregulatory roles by attenuating autologous CD8(+) T cell response in SAA.
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