Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 76, Issue 7, Pages 1365-1380Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-2995-5
Keywords
Myocardial infarction; Macrophages; Neutrophils; Scar formation; Scar resolution; Neonatal mice; Salamander; Zebrafish; Medaka; Comparative analysis
Categories
Funding
- Max Planck Society
- EU (ERC)
- DFG
- Leducq Foundation
- Academia Sinica
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Immediately after cardiac injury, the immune system plays major roles in repair and regeneration as it becomes involved in a number of processes including damage-associated signaling, inflammation, revascularization, cardiomyocyte dedifferentiation and replenishment, and fibrotic scar formation/resolution. Recent studies have revealed that different immune responses occur in the various experimental models capable or incapable of cardiac regeneration, and that harnessing these immune responses might improve cardiac repair. In light of this concept, this review analyzes current knowledge about the immune responses to cardiac injury from a comparative perspective. Insights gained from such comparative analyses may provide ways to modulate the immune response as a potential therapeutic strategy for cardiac disease.
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