Journal
CELLULAR AND MOLECULAR LIFE SCIENCES
Volume 76, Issue 8, Pages 1459-1471Publisher
SPRINGER BASEL AG
DOI: 10.1007/s00018-018-3000-z
Keywords
Embryonic stem cells; LncRNAs; Ultraconserved elements; T-UCEs
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Funding
- TRANSCAN-2 Project BeFIT, AIRC [IG 20736]
- Epigenomics Flagship Project (EPIGEN) MIUR-CNR
- Italian Ministry of Education-University-Research [CTN01_00177 Cluster ALISEI_IRMI]
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LncRNAs have recently emerged as new and fundamental transcriptional and post-transcriptional regulators acting at multiple levels of gene expression. Indeed, lncRNAs participate in a wide variety of stem cell and developmental processes, acting in cis and/or in trans in the nuclear and/or in the cytoplasmic compartments, and generating an intricate network of interactions with RNAs, enhancers, and chromatin-modifier complexes. Given the versatility of these molecules to operate in different subcellular compartments, via different modes of action and with different target specificity, the interest in this research field is rapidly growing. Here, we review recent progress in defining the functional role of lncRNAs in stem cell biology with a specific focus on the underlying mechanisms. We also discuss recent findings on a new family of evolutionary conserved lncRNAs transcribed from ultraconserved elements, which show perfect conservation between human, mouse, and rat genomes, and that are emerging as new player in this complex scenario.
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