Journal
CELL STEM CELL
Volume 23, Issue 4, Pages 466-467Publisher
CELL PRESS
DOI: 10.1016/j.stem.2018.09.015
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Modeling ALS remains a major challenge since the vast majority of cases are sporadic. Recently in Nature Medicine, Fujimori et al. leverage genetic heterogeneity and define subgroups of iPSC-derived motor neurons using multiplex phenotypic profiles, and thus make substantial progress toward robust modeling of both familial and sporadic ALS.
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