Journal
CELL METABOLISM
Volume 29, Issue 4, Pages 844-+Publisher
CELL PRESS
DOI: 10.1016/j.cmet.2018.12.007
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Funding
- TrygFonden
- Danish Council for Strategic Research [09-067009, 09-075724]
- Oak Foundation [OCAY-13-309]
- Danish Diabetes Academy
- Novo Nordisk Foundation
- Danish Heart Foundation [16-R107-A6704-22970]
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Visceral adipose tissue is harmful to metabolic health. Exercise training reduces visceral adipose tissue mass, but the underlying mechanisms are not known. Interleukin-6 (IL-6) stimulates lipolysis and is released from skeletal muscle during exercise. We hypothesized that exercise-induced reductions in visceral adipose tissue mass are mediated by IL-6. In this randomized placebo-controlled trial, we assigned abdominally obese adults to tocilizumab (IL-6 receptor antibody) or placebo during a 12-week intervention with either bicycle exercise or no exercise. While exercise reduced visceral adipose tissue mass, this effect of exercise was abolished in the presence of IL-6 blockade. Changes in body weight and total adipose tissue mass showed similar tendencies, whereas lean body mass did not differ between groups. Also, IL-6 blockade increased cholesterol levels, an effect not reversed by exercise. Thus, IL-6 is required for exercise to reduce visceral adipose tissue mass and emphasizes a potentially important metabolic consequence of IL-6 blockade.
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