Journal
CELL COMMUNICATION AND SIGNALING
Volume 16, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s12964-018-0277-3
Keywords
Redox disproportionation and speciation of copper; Dynamic copper pool; Copper-rich aggregates; GSH; GSSG ratio; Copper chelate therapy; Neuro-glia coupling
Categories
Funding
- [KMR_12-1-2012-0112 TRANSRAT]
- [VEKOP-2.1.1-15-2016-00156]
- [OTKA K124558]
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Copper-containing enzymes perform fundamental functions by activating dioxygen (O-2) and therefore allowing chemical energy-transfer for aerobic metabolism. The copper-dependence of O-2 transport, metabolism and production of signalling molecules are supported by molecular systems that regulate and preserve tightly-bound static and weakly-bound dynamic cellular copper pools. Disruption of the reducing intracellular environment, characterized by glutathione shortage and ambient Cu(II) abundance drives oxidative stress and interferes with the bidirectional, copper-dependent communication between neurons and astrocytes, eventually leading to various brain disease forms. A deeper understanding of of the regulatory effects of copper on neuro-glia coupling via polyamine metabolism may reveal novel copper signalling functions and new directions for therapeutic intervention in brain disorders associated with aberrant copper metabolism.
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