Journal
CELL
Volume 175, Issue 6, Pages 1457-1459Publisher
CELL PRESS
DOI: 10.1016/j.cell.2018.11.020
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Funding
- Wellcome Trust [203249/Z/16/Z] Funding Source: Wellcome Trust
- Wellcome Trust [203249/Z/16/Z] Funding Source: Medline
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The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.
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