4.8 Editorial Material

Mechanobiology of Protein Droplets: Force Arises from Disorder

Journal

CELL
Volume 175, Issue 6, Pages 1457-1459

Publisher

CELL PRESS
DOI: 10.1016/j.cell.2018.11.020

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Funding

  1. Wellcome Trust [203249/Z/16/Z] Funding Source: Wellcome Trust
  2. Wellcome Trust [203249/Z/16/Z] Funding Source: Medline

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The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et. al., 2018; Shin et al., 2018). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.

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