Journal
CARCINOGENESIS
Volume 40, Issue 2, Pages 380-391Publisher
OXFORD UNIV PRESS
DOI: 10.1093/carcin/bgy143
Keywords
-
Categories
Funding
- National Natural Science Foundation of China [81572787, 81672683, 81672993, 81772928, 81702907, 21806186, 31741049, 81803025, 81772901]
- Overseas Expertise Introduction Project for Discipline Innovation (111 Project) [111-212]
- Natural Science Foundation of Hunan Province [2016JC2035, 2017SK2105, 2018JJ3815, 2018SK21210, 2018SK21211, 2018JJ3704]
Ask authors/readers for more resources
Nasopharyngeal carcinoma (NPC) is a unique malignant cancer with high metastasis. Because the early symptoms of NPC patients are not obvious, most patients have distant metastases when diagnosed, which makes treatment difficult. Long non-coding RNAs (lncRNAs) are emerging as important regulators in human carcinogenesis. LncRNAs have been increasingly identified but remain largely unknown in NPC. Therefore, we performed gene expression profiling to screen for altered expression of lncRNAs in NPC tissues and adjacent samples. One lncRNA, LOC284454, was upregulated and associated with poor prognosis in NPC. In in vivo and in vitro assays, LOC284454 promoted the migration and invasion capacity of NPC cells. Mass spectrometry combined with bioinformatics suggested that LOC284454 affected the cytoskeletal and adhesion-related Rho/Rac signaling pathways. LOC284454 may be a potential novel treatment target and is expected to be a new diagnostic and prognostic marker in patients with NPC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available